Hlzle E, Plewig G, von Kries R, Lehmann P. J Invest Dermatol. The exact cause of PMLE is unknown. Gruber-Wackernagel A, Byrne SN, Wolf P. Polymorphous light eruption: clinic aspects and pathogenesis. There arent any severe physical complications strongly associated with PMLE, but a severe case of the condition may lead to: If you have PMLE and you find that its affecting your well-being, a healthcare professional can advise you on appropriate strategies to manage these feelings. The lesions are itching or burning, and . [16], The preponderance in women with a decline in severity following menopause has been thought to be associated with oestrogen effects,[6] A natural fall in oestrogens may account for the tendency to remit after the menopause. The photo antigen that triggers this response is currently unknown. [2], The main differential diagnosis is photosensitivity associated with lupus erythematosus, which may behave and appear similar but tends to be more persistent. Polymorphous light eruption (PMLE). Your provider may refer to this as hardening the skin. You should only attempt this type of desensitization while under your providers care. Distribution can include areas exposed to sunlight such as the arms, lower legs, V of the neck, and the chest. Other medications that might be used to treat PMLE include: If you have an unexplained rash, you should make an appointment with a primary care physician or dermatologist. Elsevier; 2021. https://www.clinicalkey.com. If you can't avoid the sun, use a broad-spectrum sunscreen with an SPF of at least 30 in areas that cannot be protected by clothing. [10] It is also thought that skin microbiome or microbial elements could be involved in pathogenesis of the disease [13][14], PLE can be provoked by UVA or UVB (chief cause of sunburn) rays, meaning it can be triggered even by sunlight through glass. For utmost sun protection, use your sunscreen before the stated expiration date. and transmitted securely. It most often (about 75% of cases) begins in females aged 20 to 40 years but may start in childhood or later in life. This is a type of distinct, circular bump that occurs due to, Erythema multiforme causes a distinctive rash resembling a bull's-eye.
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