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Health Encyclopedia - University of Rochester Medical Center Proteins play many important roles, including providing energy for the body, rebuilding muscles, and supporting the immune system. Your results will show that your protein levels are in the normal range, too high, or too low. There is very little risk to having a blood test. Testing a 24-hour urine sample allows for an accurate measurement of the level of kidney function and can indicate possible kidney damage from myeloma. Proteins play many important roles, including providing energy for the body, rebuilding muscles, and supporting the immune system. what does no apparent monoclonal protein on serum electrophoresis mean. . Rajhumar SV. [18, 19], Detection of a paraprotein by immunofixation is possible in lymphomas. Sometimes a CBC with differential (CBC with diff), a test that also measures the number of the different types of white blood cells present in the blood, is ordered. In addition, when protein electrophoresis assays are positive for a monoclonal protein, serum and urine immunofixation are indicated for the appropriate identification of the immunoglobulin and the corresponding light chain. Evidence of end-organ damage as defined by the CRAB criteria. Here are my blood test results for "Interpretation" part. Murray DL, Puig N, Kristinsson S, et al. 95:2126-33. As denoted in the normal curve above, antibodies are primarily found in the fraction. Follow-up of multiple myeloma, Waldenstrom macroglobulinemia, and AL amyloidosis, Immunofixation of urine and serum samples should be performed in all patients with multiple myeloma, Waldenstrom macroglobulinemia, and AL amyloidosis every 3 months after the completion of treatment in order to evaluate for response or to document a relapse. 2015 Oct. 47 (6):564-9. In particular, when serum and urine protein electrophoresis results are negative, immunofixation is indicated as a more sensitive test if the clinical suspicion remains high. What specimens can be used to perform an immunofixation test? This article provides a comprehensive review of serum protein electrophoresis, including a discussion of how the examination is performed, what it measures, and when it is indicated. 2017 Dec 28. The remainder had hypogammaglobulinemia or a normal-appearing pattern. Medscape Drugs & Diseases. [QxMD MEDLINE Link]. Hematocrit is a blood test that is used to determine if you have low levels of hemoglobin in your blood (a condition called anemia). M-Protein Antibodies and Significance in Blood - Verywell Health A total protein test is often done as part of your regular checkup. The proteins are separated into 5 or 6 fractions and displayed as a curve and corresponding gel pattern. These proteins can also be referred to as an M-spike, monoclonal immunoglobulin, or paraprotein. Plasma protein levels display reasonably predictable changes in response to acute inflammation, malignancy, trauma, necrosis, infarction, burns, and chemical injury. The identification of a monoclonal immunoglobulin is helpful in the diagnosis of the following conditions Thanks for helping me with this quality post. Immunofixation in CSF for the detection of oligoclonal bands is indicated every time there is suspicion for multiple sclerosis.