Black Person Uncombable Hair Syndrome, Articles I

Exposure could cause death. (d) The MARINE POLLUTANT mark is not required -. Hexachlorocyclohexane UN Hazard Class: 6.1; UN Pack Group: III, Prepared by an international group of experts on behalf of ILO and WHO, startxref 0 [1] Alpha- and beta-HCH were used agriculturally in the U.S. in the form of technical-grade HCH until 1976 and are also produced as manufacturing by-products but are void of insecticidal properties and have little to no use. ILO and WHO 2021. 0000002858 00000 n [28] More specifically, the EPA conducted down-the-drain estimates of the amount of lindane reaching public water supplies from the use of lindane medications using data from California water treatment facilities, concluding that lindane levels from pharmaceutical sources were extremely low and not of concern.[5]. This produces toxic and corrosive fumes including chlorine (see ICSC 0126), hydrogen chloride (see ICSC 0163) and phosgene (see ICSC 0007). Lindane is a neurotoxin that interferes with GABA neurotransmitter function by interacting with the GABAA receptor-chloride channel complex at the picrotoxin binding site. Inhalation risk [7][16], In all age groups, reported adverse events occurred mainly in patients with contraindications to the use of lindane or in those who appeared to have misapplied or orally ingested medication. pollution In the 1940s, lindane was registered with the U.S. Department of Agriculture (USDA), and in 1951 it was approved by the U.S. Food and Drug Administration (FDA) for medical use in the treatment of scabies, head lice and pubic lice (crabs). Further see Ingestion. In 1987, the International Agency for Research on Cancer (IARC) classified lindane as a possible human carcinogen. [1] [7], In 1995, lindane medications were designated second-line and are now reserved for patients who are unable to tolerate or have failed first-line treatmentsa growing problem in the U.S. and elsewhere due to increased rates of resistance. (4) For domestic transportation, a packaging marked prior to January 1, 2017 and in conformance with the requirements of this paragraph in effect on December 31, 2014, may continue in service until the end of its useful life.