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However, it is essential to be able to differentiate these lesions from other benign and malignant skin tumors. Ophthalmology. Careers. Hydrogen Peroxide 40% for the Treatment of Seborrheic Keratoses. HP40 is a promising topical alternative, particularly for cosmetically sensitive locations, such as the face. Jackson JM, Alexis A, Berman B, Berson D, Taylor S, Weiss J. While additional clinical studies are needed to explore this assertion, HP40 may destroy fewer melanocytes than cryotherapy, meaning that HP40 may be a potentially beneficial therapy for patients with dark skin who are susceptible to pigmentary changes with cryotherapy.7 On the contrary, because of the high cost of HP40 and need for repeat treatments, it is likely less useful for symptomatic SKs in non-cosmetically sensitive locations where patients desire rapid relief without as much concern about the cosmetic outcomes. Med Lett Drugs Ther. [9] This method is efficacious and generally well tolerated by the patient. Shave excision of common acquired melanocytic nevi: cosmetic outcome, recurrences, and complications. 2016; 3(2): 26872. Half of them were given cod liver oil and the other half placebo, taken daily during the winter. 2018 Oct 1;17(10):1092-1098. PMID: 15283223. There are two types of lasers utilized for the treatment of seborrheic keratosis, including ablative and non- ablative laser therapy. Induction of terminal differentiation in melanoma cells on downregulation of beta-amyloid precursor protein. 2006 Apr;81(4):217-9. Hydrogen Peroxide 40% Monograph for Professionals - Drugs.com Basal cell carcinoma arising from SK has also been reported. The other study was conducted in Norway (BMJ, Sept. 7, 2022). [11] Patients may note slow growth of these lesions, pain, pruritis, erythema, bleeding, or may have no symptoms at all. Managing Seborrheic Keratosis: Evolving Strategies and Optimal Therapeutic Outcomes. Natarelli N, Krenitsky A, Hennessy K, Moore S, Grichnik J. J Dermatolog Treat. The .gov means its official. Common adverse reactions include erythema (99%), stinging (97%), edema (91%), scaling (90%), crusting (81%), and pruritus (58%). Considerations should include the lesion size and thickness, the patients skin type, clinical suspicion for malignancy, and the physicians clinical experience. Keep in mind that the concentration that you get over the counter may not be high enough to destroy seborrheic keratosis but it still works and many people go with it. HP40 is applied by a healthcare professional with a single use pen that includes 0.7 mL of 40% H 2 O 2 and can treat about seven SKs. Ann Dermatol. [6][7] A recent study found an average of 69 SK lesions per person in individuals over the age of 75. After the treatment, people may experience redness, burning, stinging, swelling, blistering or itching. for seborrheic keratosis Available from: https://www.ncbi.nlm.nih.gov/books/NBK470554/. The side effects of treatment were generally mild and included erythema, scaling, and hyperpigmentation. While the risks of pigmentary changes and scarring at day 106 were low, especially for facial SKs, 98.8% of the study sample were FST I-IV, with only 7.3% having FST IV, so the effects on patients with FST IV or higher could not be adequately assessed.20 A study by Kao et al. Managing Seborrheic Keratoses: Evolving Strategies for Optimizing Patient Outcomes. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG.